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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG1
All Species:
20.91
Human Site:
Y519
Identified Species:
41.82
UniProt:
P19174
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19174
NP_002651.2
1290
148532
Y519
L
T
S
S
K
I
Y
Y
S
E
E
T
S
S
D
Chimpanzee
Pan troglodytes
XP_514650
1630
185027
Y859
L
T
S
S
K
I
Y
Y
S
E
E
T
S
S
D
Rhesus Macaque
Macaca mulatta
XP_001087295
1291
148567
Y519
L
T
S
S
K
I
Y
Y
S
E
E
T
S
S
D
Dog
Lupus familis
XP_542998
1249
143812
E497
E
D
E
E
E
P
K
E
A
S
G
S
T
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q62077
1302
149650
Y519
L
T
S
S
K
I
Y
Y
S
E
E
T
S
S
D
Rat
Rattus norvegicus
P10686
1290
148530
Y519
L
T
S
S
K
I
Y
Y
S
E
E
T
S
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q2VRL0
637
72514
Frog
Xenopus laevis
Q32NH8
758
87399
D65
K
S
T
F
S
I
S
D
I
E
T
V
R
E
G
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
V91
Q
T
F
S
V
T
E
V
E
C
V
R
E
G
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13217
1095
124845
A402
I
Q
A
I
A
D
C
A
F
V
S
S
E
Y
P
Honey Bee
Apis mellifera
XP_624101
1134
132613
Y441
L
T
Q
Q
K
L
F
Y
T
D
T
F
S
R
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
M247
Y
S
L
S
F
W
A
M
G
K
V
N
H
C
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79
99.5
93.2
N.A.
95.3
96.9
N.A.
N.A.
21.4
21.7
21.8
N.A.
21.4
45.1
N.A.
35.1
Protein Similarity:
100
79
99.7
94.5
N.A.
96.7
98.2
N.A.
N.A.
32.4
37.3
36.3
N.A.
40
62
N.A.
50
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
N.A.
0
13.3
13.3
N.A.
0
33.3
N.A.
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
N.A.
0
26.6
13.3
N.A.
20
60
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
9
0
9
9
9
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
9
0
0
9
0
0
0
9
9
% C
% Asp:
0
9
0
0
0
9
0
9
0
9
0
0
0
0
42
% D
% Glu:
9
0
9
9
9
0
9
9
9
50
42
0
17
17
0
% E
% Phe:
0
0
9
9
9
0
9
0
9
0
0
9
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
9
0
9
0
0
9
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
9
0
0
9
0
50
0
0
9
0
0
0
0
0
0
% I
% Lys:
9
0
0
0
50
0
9
0
0
9
0
0
0
0
0
% K
% Leu:
50
0
9
0
0
9
0
0
0
0
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% N
% Pro:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
9
% P
% Gln:
9
9
9
9
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
9
9
9
9
% R
% Ser:
0
17
42
59
9
0
9
0
42
9
9
17
50
42
0
% S
% Thr:
0
59
9
0
0
9
0
0
9
0
17
42
9
0
9
% T
% Val:
0
0
0
0
9
0
0
9
0
9
17
9
0
0
0
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
42
50
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _